• ID Zelnik, AE Ventura, J Kim, LC Silva, AH Futerman (2019) "The role of ceramide in regulating endoplasmic reticulum function", Biochim Biophys Acta – Mol Cell Biol Lipids, in press, doi: 10.1016/j.bbalip.2019.06.015

  • AE Ventura, B Mestre and Liana C. Silva*, (2019) “Ceramide domains in health and disease: a biophysical perspective” In: J Stiban (Eds) “Bioactive ceramides in health and disease: Intertwined roles of enigmatic lipids”, book series: Advances in Experimental Medicine and Biology, Springer Nature, Switzerland, in press,  

  • AC Carreira, TC Santos, MA Lone, E Zupancic, E Lloyd-Evans, RFM de Almeida, T Hornemann, LC Silva (2019) "Mammalian sphingoid bases: biophysical, physiological and pathological properties", Prog Lipid Research, 75:100988, doi: 10.1016/j.plipres.2019.100988

  • M. A. Lone, T. Santos, I. Alecu, L.C. Silva, T. Hornemann (2019) “1-deoxy-sphingolipids”, Biochim Biophys Acta – Mol Cell Biol Lipids,  1864(4):512-521, doi:10.1016/j.bbalip.2018.12.013

  • N Martinho, TC Santos, HF Florindo, LC Silva (2019), “Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity”, Frontiers in Physiology, 9, doi: 10.3389/fphys.2018.01898


  • R. Lopes, A. Ventura, L. Silva, H. Faustino, P.M.P. Góis (2018) “N,O‐Iminoboronates: Reversible Iminoboronates with Improved Stability for Cancer Cells Targeted Delivery” Chem Eur J, 24(48):12495-12499 doi:10.1002/chem.20180215

  • Ana Luísa Silva, Liane Moura, Bárbara Carreira, João Conniot, Ana I Matos, Carina Peres, Vanessa Sainz, Liana C. Silva, Rogério S. Gaspar, Helena F. Florindo* (2018) “Functional Moieties for Intracellular Traffic of Nanomaterials” In:  Bruno Sarmento, José das Neves (Eds) “Biomedical Applications of Functionalized Nanomaterials”, Chapter 14, Elsevier, Philadelphia, United States, ISBN: 9780323508780; doi:10.1016/B978-0-323-50878-0.00014-8



  • A. G. dos Santos,  J. T. Marquês,  A. C. Carreira,  I. R. Castro,  A. S. Viana,  M.-P. Mingeot-Leclercq,  R. F. M. de Almeida*  and  L. C. Silva (2017), “The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition”, Phys Chem Chem Phys, 19, 30078-30088, doi:10.1039/C7CP05353C

  • Martinho N, Silva LC, Florindo HF, Brocchini S, Zloh M, Barata TS (2017), “Rational design of novel, fluorescent, tagged glutamic acid dendrimers with different terminal groups and in silico analysis of their properties”, Int J Nanomedicine, 12, 7053–7073, doi:10.2147/IJN.S135475

  • Martinho N, Silva LC, Florindo HF, Brocchini S, Barata T, Zloh M (2017), Practical computational toolkits for dendrimers and dendrons structure design”, J Comput Aided Mol Des, 9, 817-827, doi: 10.1007/s10822-017-0041-6.

  • Moura LIF, Martinho N, Silva LC, Barata TS, Brocchini S, Florindo HF, Zloh M. (2017) “Poly-glutamic dendrimer-based conjugates for cancer vaccination – a computational design for targeted delivery of antigens”, J Drug Target, 10, 1-8. doi: 10.1080/1061186X.2017.1363213

  • Dos Santos AG, Bayiha JC, Dufour G, Cataldo D, Evrard B, Silva LC, Deleu M, Mingeot-Leclercq MP (2017), “Changes in membrane biophysical properties induced by the Budesonide/Hydroxypropyl-β-cyclodextrin complex”, Biochim Biophys Acta, 1859(10),1930-1940. doi: 10.1016/j.bbamem.2017.06.010

  • Ana C Carreira, Rodrigo F.M. de Almeida, Liana C. Silva (2017) “Development of lysosome-mimicking vesicles to study the effect of abnormal accumulation of sphingosine on membrane properties” Sci Rep. 7(1), 3949 doi: 10.1038/s41598-017-04125-6.

  • Ana R.P. Varela, Ana E. Ventura, Ana C. Carreira, Alexander Fedorov, Anthony H. Futerman, Manuel Prieto, Liana C. Silva (2017) “Pathological levels of glucosylceramide change the biophysical properties of artificial and cell membranes”, Phys Chem Chem Phys, 19, 340-346 doi: 10.1039/C6CP07227E

  • Ana R.P. Varela, André Sá Couto, Alexander Fedorov, Anthony H. Futerman, Manuel Prieto, Liana C. Silva (2016) “Glucosylceramide reorganizes cholesterol-containing domains in a fluid phospholipid membrane”, Biophys J, 110 (3): 612-622. doi: 10.1016/j.bpj.2015.12.019

  • Fábio M.F. Santos, João N. Rosa, Nuno R. Candeias, Cátia P. Carvalho, Ana I. Matos, Ana E. Ventura, Helena F. Florindo, Liana C. Silva, Uwe Pischel, Pedro M.P. Góis (2016) “A Three-Component Assembly Pomoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)”, Chem Eur J, 22 (5): 1631-1637, doi: 10.1002/chem.201503943

  • Ana E. Ventura, Tânia Santos, Ana. C. Carreira, Nuno M. Martinho, J. Conniot, Ana R. Varela, Rogério Gaspar, Helena F. Florindo, Liana C. Silva (2016) “Drugs, delivery systems and membrane organization in model and cell membranes.” In: Angel Catala (Eds) “Membrane organization and lipid rafts in the cell and artificial membranes”, Chapter 4, Nova Science Publishers Inc, New York, ISBN: 978-1-63484-589-2

  • H.F. Florindo, J. Lopes, Liana C. Silva,  M.L. Corvo, M.B. Martins, R. Gaspar* (2016) “Regulatory development of nanotechnology-based vaccines", In: Micro and Nanotechnology in Vaccine Development, edited by Dr Mariusz Skwarczynski and Professor Istvan Toth, Elsevier ISBN: 978-0-323-39981-4;



  • João Conniot, Joana M. Silva, Joana G. Fernandes, Liana C. Silva, Rogério Gaspar, Steve Brocchini, Helena Florindo, Teresa Barata, (2014) “Cancer immunotherapy: role of nanodelivery approaches for combined targeting and tracking of immune cells”, Frontiers in Chemistry, Research Topic: Cancer Nanotheranostics: What have we learned so far? Front. Chem, 2:105. doi: 10.3389/fchem.2014.00105 

  • [OA] Nuno Martinho, Helena Florindo, Liana Silva, Steve Brocchini, Mire Zloh and Teresa Barata (2014), “Molecular Modeling for Dendrimers' Design and Biomedical Applications”, Molecules, 19 (12), 20424-20467  doi: 10.3390/molecules191220424.

  • Joana M. Silva, Gaëlle Vandermeulen, Vanessa G. Oliveira, Sandra N. Pinto, Catarina Rodrigues, Carlos A. Afonso, Christine Jérôme, Liana C. Silva, Luis Graça, Véronique Préat, Helena F. Florindo (2014) “Development of Functionalized Nanoparticles for Vaccine Delivery to Dendritic Cells: a Mechanistic Approach” Nanomedicines, 9 (17), 2639-2669 doi: 10.2217/mnm.14.135

  • Eva Zupancic, Ana Carreira, Rodrigo F. M. de Almeida, Liana C. Silva (2014) “Biophysical Implications of sphingosine accumulation in membrane properties at neutral and acidic pH” J. Phys. Chem. B, 118 (18): 4858-4866 doi: 10.1021/jp501167f

  • Ana R.P. Varela, Amélia M.P.S. Gonçalves da Silva, Alexander Fedorov, Anthony H. Futerman, Manuel Prieto, Liana C. Silva, (2014) “Influence of intracellular membrane pH on sphingolipid organization and membrane biophysical properties” Langmuir , 30: 4094-4104 doi: 10.1021/la5003397

  • Bruno M. Castro, Manuel Prieto, Liana C. Silva (2014) “Ceramide: a simple sphingolipid with unique biophysical properties”, Prog Lipid Res, 54: 53-67 doi: 10.1016/j.plipres.2014.01.004

  • Sandra N. Pinto, Elad L. Laviad, Johnny Stiban, Samuel L. Kelly, Alfred H. Merrill, Manuel Prieto, Anthony H. Futerman, Liana C. Silva, (2014) “Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain”, J. Lip. Res., 55: 53-61 doi: 10.1194/jlr.M042002.

  • R. Gaspar*, H.F. Florindo, Liana C. Silva, M. Videira, L. Corvo, B. Martins, B. Silva-Lima (2014), “Translational aspects of nano-oncologicals”, In: M.J. Alonso & M. Garcia-Fuentes (Eds) “Nano-oncologicals: new targeting and delivery approaches”, Chapter 15, Controlled Release Society and Springer, US, ISBN: 978-3-319-08083-3;

  • Rodrigo F.M. de Almeida, Joaquim T. Marquês and Liana C. Silva (2014) “Biophysics of lipid rafts and their interplay with ceramide. Studies in models systems and biological insights.” In: Daniel Sillence (Eds) “Lipid Rafts: Properties, Role in Signal transduction”, Chapter 2, Nova Science Publishers Inc, New York, ISBN: 978-1-62948-964-3

  • Vanessa Sainz, João Conniot, Ana I Matos, Carina Peres, Eva Zupancic, Liane Moura, Liana C Silva, Helena F Florindo, Rogério S Gaspar (2015) “Regulatory aspects on nanomedicine”, Biochem Biophys Res Commun, 468 (3): 504-510. doi:10.1016/j.bbrc.2015.08.023

  • Ana C. Carreira, Ana E. Ventura, Ana R.P. Varela, Liana C. Silva, (2015) “Tackling the biophysical properties of sphingolipids to decipher their biological roles”, Biol Chem, 396 (6-7): 597-609, doi: 10.1515/hsz-2014-0283


  • Sandra N. Pinto, Fábio Fernandes, Alexander Fedorov, Anthony H. Futerman, Liana C. Silva*, Manuel Prieto* (2013) “A combined fluorescence spectroscopy, confocal and 2-photon microscopy to re-evaluate the properties of sphingolipid domains”, Biochim. Biophys. Acta, 1828 (9): 2099-2110 doi: 10.1016/j.bbamem.2013.05.011

  • Ana R.P. Varela, Amélia M.P.S. Gonçalves da Silva, Alexander Fedorov, Anthony H. Futerman, Manuel Prieto & Liana C. Silva (2013) "Effect of glucosylceramide on the biophysical properties of fluid membranes", Biochim. Biophys. Acta, 1828 (3): 1122-1130 doi: 10.1016/j.bbamem.2012.11.018

  • J. Silva, E. Zupancic, C. Peres, L.C. Silva, R. Gaspar, V. Préat and H F Florindo (2013),  “Immunomodulation against microbial pathogens through dendritic cells”, in “Microbial pathogens and strategies for combating them: science, technology and education”, A. Méndez-Vilas(Eds), Formatex Research Center, ISBN (13) Volume 3: 978-84-942134-1-0


  • Liana C. Silva, Oshrit Ben-David, Yael Pewzner-Jung, Elad L. Laviad, Johnny Stiban, Sibali Bandyopadhyay, Alfred H. Merrill Jr., Manuel Prieto & Anthony H. Futerman (2012) “Ablation of Ceramide Synthase 2 strongly affects biophysical properties of membranes”, J. Lip. Res., 53: 430-436 doi:10.1194/jlr.M022715

  • Arpita Singh, Haitao Wang, Liana C. Silva, Chongzheng Na, Manuel Prieto, Anthony H. Futerman, Chiara Luberto & Maurizio Del Poeta, (2012) “Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans", Cell. Microbiol., 54, 500-516 doi: 10.1111/j.1462-5822.2011.01735.x.


  • Sandra N Pinto, Liana C Silva, Anthony H Futerman & Manuel Prieto (2011) “Effect of ceramide structure on membrane biophysical properties:  the role of acyl chain length and unsaturation” (Biochim Biophys Acta, 1808 (11): 2753-60.  doi: 10.1016/j.bbamem.2011.07.023.


  • YP-Jung, H Park, EL Laviad, LC Silva, S Lahiri, J Stiban, RE-Roman, B Brüger, T Sachsenheimer, F Wieland, M Prieto, AH Merrill Jr & AH Futerman (2010) “A critical role for Ceramide Synthase 2 in liver homeostasis: I. Alterations in lipid metabolic pathways” J. Biol. Chem., 285: 10902-10. doi: 10.1074/jbc.M109.077594.


  • BM Castro, LC Silva, A Fedorov, RFM de Almeida & M. Prieto (2009) “Cholesterol-rich fluid membranes solubilize ceramide domains. Implications for the structure and dynamics of mammalian intracellular and plasma membranes”, J. Biol. Chem 284: 22978-87. doi: 10.1074/jbc.M109.026567.

  • Liana C. Silva, Anthony H. Futerman and Manuel Prieto (2009) “Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations”, Biophy. J., 96 (8): 3210-22. doi:10.1016/j.bpj.2008.12.3923.

  • Luís Loura, Rodrigo F.M. de Almeida, Liana C. Silva and Manuel Prieto (2009) “FRET analysis of domain formation and properties in complex membrane systems” Biochim. Biophys. Acta., 1788 (1), 209-224. doi:10.1016/j.bbamem.2008.10.012.


  • Johnny Stiban, Liana C. Silva and Anthony H Futerman (2008) “Ceramide-containing membranes: the interface between biophysics and biology” Trends Glycosci. Glycotechnol., 20, 297-313. doi: 10.4052/tigg.20.297.

  • Sandra N. Pinto, Liana C. Silva, Rodrigo F.M. de Almeida and Manuel Prieto (2008) “Membrane domain formation, interdigitation and morphological alterations induced by the very long chain asymmetric C24:1 ceramide”, Biophys J., 95, 2867-2879. doi:10.1529/biophysj.108.129858.


  • Bruno M. Castro, Rodrigo F.M. de Almeida, Liana C. Silva, Alexander Fedorov and Manuel Prieto (2007) “Formation of ceramide/sphingomyelin gel domains in the presence of an unsaturated phospholipids: a quantitative multiprobe approach”, Biophys. J., 93, 1639-1650. doi:10.1529/biophysj.107.107714.

  • Liana C. Silva, Rodrigo F.M. de Almeida, Bruno M. Castro, Alexander Fedorov and Manuel Prieto (2007) “Ceramide-domain formation and collapse in lipid rafts: membrane reorganization by an apoptotic lipid”, Biophys. J., 92 (2), 502-516. doi:10.1529/biophysj.106.091876.


  • Liana Silva, Ana Coutinho, Alexander Fedorov and Manuel Prieto (2006) “Nystatin-induced lipid vesicles permeabilization is strongly dependent on sterol structure”, Biochim. Biophys. Acta, 1758 (4), 452-459. doi: 10.1016/j.bbamem.2006.03.008.

  • Liana Silva, Ana Coutinho, Alexander Fedorov and Manuel Prieto (2006) “Competitive binding of cholesterol and ergosterol to the polyene antibiotic nystatin. A fluorescence study.” Biophys. J., 90 (10), 3625-3631. doi:10.1529/biophysj.105.075408.

  • Liana Silva, Rodrigo F.M. de Almeida, Alexander Fedorov, António P.A. Matos and Manuel Prieto (2006) “Ceramide-platform formation and -induced biophysical changes in a fluid phospholipid membrane.” Mol. Memb. Biol., 23 (2), 137-148. doi:10.1080/09687860500439474.


  • Ana Coutinho, Liana Silva, Alexander Fedorov and Manuel Prieto (2004) “Cholesterol and ergosterol influence nystatin surface aggregation: Relation to pore formation.” Biophys. J., 87: 3264-3276. doi:10.1529/biophysj.104.044883.


  • Liana Silva, Ana Coutinho, Alexander Fedorov and Manuel Prieto (2003) “Conformation and self-assembly of a nystatin nitrobenzoxadiazole derivative in lipid membranes.” Biochim. Biophys. Acta, 1617 (1-2): 69-79. doi: 10.1016/j.bbamem.2003.09.004.

  • Liana Silva, Ana Coutinho, Alexander Fedorov and Manuel Prieto (2003) “Solution conformation of a nitrobenzoxadiazole derivative of the polyene antibiotic Nystatin. A FRET study.” J. Photochem. Photobiol. B, 72 (1-3): 17-26. doi: 10.1016/j.jphotobiol.2003.08.005.


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